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Home > Medicine > Clinical & internal medicine > Zusammenfassung von O'Leary und Igdouras The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis
Zusammenfassung von O'Leary und Igdouras The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis

Zusammenfassung von O'Leary und Igdouras The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis


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About the Book

Zusammenfassung aus dem Jahr 2015 im Fachbereich Medizin - Neurologie, Psychiatrie, Süchte, Note: keine Notenvergabe, Universität Wien, Veranstaltung: SSM1/ Block7, Sprache: Deutsch, Abstract: Oft fällt es Medizinstudenten schwer eine englischsprachige Publikation eines medizinischen Journals zu verstehen. Vor allem am Anfang kann es hilfreich sein die korrekte deutsche Übersetzung mit der englischen Originalarbeit zu vergleichen. Diese Seminararbeit bietet die Möglichkeit dazu: Die wichtigsten Punkte sind wortwörtlich übersetzt, andere Teile bieten eine übersichtliche Zusammenfassung. Die Originalarbeit in englischer Sprache ist in den Universitätsbibliotheken für jeden Medizinstudenten frei zugänglich. Sialidose ist eine autosomal rezessive Erkrankung, welche durch die gestörte Funktion von Sailidase Enzymen hervorgerufen wird. Sie wird in zwei Phänotypen unterteilt, Sialidose Typ I und II, Sialidose ist eine sehr heterogene Erkrankung mit variierenden Alter des Auftretens und Patologien. Derzeit gibt es keine brauchbare Therapie für die Behandlung von Sialidose Patienten. Auf molekularer Ebene zeigen die Zellen von Sialidose Patienten die (zusammengesetzte) heterozygote Mutationen aufweisen eine unsachgemäße Enzymfaltung, den Verlust der Aktivität des Sialidase Enzyms und deswegen eine Anhäufung von Sialidase Konjugaten innerhalb der Lysosome. Eine vielversprechende Behandlungsmöglichkeit stellt die Verwendung von kleinen pharmakologischen Molekülen dar, um die enzymatische Aktivität der mutierten Proteine zu erhöhen. In dieser Studie untersuchten wir sowohl die Wirksamkeit eines Immunsupressivums (Celastrol) als auch die eines proteosomalen Inhibitors (MG132) um mutierte Enzyme mit alarmierender Konformation zu retten. Unsere Ergebnisse offenbarten, dass MG132 die Enzymaktivität erweitert und dass es in Zellen, welche fehlerhafte Sialidase besitzen, lokalisiert ist. Wir fanden außerdem heraus dass MG123 die Anhäufung der Gangliosid Produkten GT1b, GD3, GM3 i


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Product Details
  • ISBN-13: 9783668142176
  • Publisher: Grin Publishing
  • Sub Title: Ein deutscher Überblick über die englischsprachige Publikation über die Stoff
  • ISBN-10: 3668142173
  • Publisher Date: 11 Feb 2016


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Zusammenfassung von O'Leary und Igdouras The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis
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Zusammenfassung von O'Leary und Igdouras The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis
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