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Valutazione degli estratti di foglie di Euclea crispa contro i patogeni della diarrea

Valutazione degli estratti di foglie di Euclea crispa contro i patogeni della diarrea


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About the Book

La diarrea è una malattia infantile comune con un alto tasso di mortalità. È il secondo principale killer di bambini, quasi un quinto dei bambini sotto i 5 anni muore a causa della disidratazione o della compromissione dell'immunità dovuta a un'infezione diarroica. Questo studio si proponeva quindi di valutare l'effetto dell'estratto di foglie di Euclea crispa e delle sue frazioni contro gli isolati che causano la diarrea e di determinare la dinamica del time-kill da parte delle frazioni più potenti. La suscettibilità degli isolati è stata determinata mediante diffusione in pozzetto di agar, mentre le concentrazioni minime batteriostatiche e battericide sono state determinate con il metodo della diluizione in agar. La dinamica del tempo di uccisione è stata valutata per un periodo di 120 minuti contro E. coli (1323), che rappresenta isolati Gram-negativi. La MIC più bassa (0,08 mg/ml) è stata raggiunta dalle frazioni partizionate in acetato di etile, n-butanolo e acqua, mentre quella partizionata in n-esano e cloroformio è stata di 0,16 mg/ml. La mortalità totale è stata raggiunta dalla frazione in acetato di etile a una concentrazione di 2 × MIC dopo 120 minuti di contatto. Questo studio dimostra il significativo potenziale antidiarroico degli estratti di foglie di Euclea crispa e indica anche una fonte di agenti terapeutici prontamente disponibili contro le infezioni diarroiche.


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Product Details
  • ISBN-13: 9786205622360
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 52
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 620562236X
  • Publisher Date: 25 Jan 2023
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 141 gr


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