Proteomics, multi-omics and systems biology in optic nerve regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome. The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in last decade. The potentially possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons with that in the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries. Proteomics and other functional omics (metabolomics and lipidomics) are becoming increasingly important to understand and normalize data. This is because transcriptomics is not often a mirror image of other omics and functional repertoire of molecules are amenable to more rapid modifications. Alternation of proteins, lipids, and metabolites, the latter results in shift in equilibrium from disease or disorder to normalcy. Or such interventions hold the equilibrium to prevent undergoing deeper pathologic states. The proteomics and multi-omics allow evaluation of concerted pathway convergence and identification of molecules for treatment. With respect to identification of molecules, their placement and systems biology the book will have wide swath of appeals: (1) To students, (2) To basic researchers and, (3) To clinicians in ophthalmology treating glaucoma and other optic neuropathies including traumatic optic neuropathy. The book will also be interesting to clinicians and translational scientists seeking new treatment for peripheral and central system neuropathies as mentioned above.