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Pathogenèse et options thérapeutiques du carcinome de la vésicule biliaire

Pathogenèse et options thérapeutiques du carcinome de la vésicule biliaire


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About the Book

Le cancer de la vésicule biliaire est une maladie rare qui peut être diagnostiquée fortuitement lors d'une cholécystectomie, souvent à un stade plus avancé de la maladie. La jaunisse est considérée comme un signe de mauvais augure dans la présentation du cancer de la vésicule biliaire. On pense que le proto-oncogène K-ras exerce un contrôle sur certains mécanismes de croissance et de différenciation cellulaires. Ce gène est transformé en oncogène actif par des mutations ponctuelles concentrées de manière significative dans les codons 12, 13 ou 61. La famille Ras se compose de trois gènes situés sur des chromosomes différents, codant pour les protéines homologues H-Ras, N-Ras et K-Ras de 21 kDa. p53 est le gène le plus important dans le cancer, car une seule mutation peut entraîner la genèse d'une tumeur. Les fonctions de p53 ont été diversifiées par la découverte de diverses isoformes de p53. Ces isoformes, dérivées soit d'un épissage alternatif, soit de sites de traduction différentiels, sont exprimées de manière spécifique à chaque tissu. L'influence de l'isoforme p53β sur l'activité de p53, soit par sa répression transcriptionnelle, soit par la formation d'un complexe avec p53, modulant ainsi son activité au niveau des promoteurs dépendants de p53. Les rôles des thérapies adjuvantes et néoadjuvantes dans le traitement du cancer de la vésicule biliaire restent mal élucidés.


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Product Details
  • ISBN-13: 9786208071646
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 91 gr
  • ISBN-10: 620807164X
  • Publisher Date: 10 Sep 2024
  • Height: 229 mm
  • No of Pages: 52
  • Spine Width: 3 mm
  • Width: 152 mm


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