I. Oxygen Metabolism and Health Monitoring1. Chronic Ketosis Modulates HIF1α Mediated Inflammatory Response in Rat Brain2. Event Related NIRS and EEG Analysis for Mental Stress Monitoring.3. Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability4. Updated Evaluation of Cholesterol's Influence of Oxygen Permeability5. Systems biology model of cerebral oxygen delivery and metabolism during therapeutic hypothermia: application to the piglet model6. Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model7. Two consecutive invasive surgeries utilizing Zymogen Protein C (ZPC) that enhanced patient safety and reduced costs8. Scanning Tissue-Oxygen Needle-Probe9. Transcranial photobiomodulation of clearance of beta-amyloid from the mouse brain: the effects on meningeal lymphatic drainage and blood oxygen saturation of the brain.10.Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion SyndromeII. Oxygen Measurement and Modeling11. Online assessment of hemodynamics in suctioned volume of biological tissue by the embedded Near-infrared Spectroscopy sensor.12. Skeletal Muscle Deoxygenation and its Relationship to Aerobic Capacity During Early and Late Stages of Aging.13. Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MBO2 Desaturation During Exercise.14. Relationship between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation15. Relationship between the Borg Scale Rating of Perceived Exertion and Leg Muscle Deoxygenation during Incremental Exercise in Healthy Adults16. Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients in Chronic Heart Failure.17. Reduced Scattering Coefficient During Incremental Exercise is Constant without being Affected by Changes in Muscle Oxygenation or Hemodynamics.18. Changes in the laterality of oxygenation in the prefrontal cortex and premotor area during a 20-min moderate-intensity cycling exercise19. Relationship Between Decrease of Oxygenation During Incremental Exercise, Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis20. Cerebral Oxygenation Dynamics during Incremental Exercise: Comparison of Arm Cranking and Leg Cycling21. Localization of Deep of Deep Ischemia and Hemorrhage in Preterm Infants' Head with Near Infrared Optical Tomography: A Numerical Case Study22. Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain ModelingIII. Tumor Oxygenation and Modeling23. Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis24. Functional Impact of Acidosis-regulated MicroRNAs on the Migration and Adhesion of Tumor Cells25. Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo26. An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A27. Keynote Lecture - The Warburg Effect: Historical Dogma versus Current Rationale28. The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as well as Adhesion of NCI-H358 Lung Cancer Cells29. Assessment of the probability of tumor control for prescribed doses based on imaging of oxygen partial pressure30. On the feasibility of Pulse Wave Velocity Imaging for remote assessment of physiological functions31. Mechanisms of sound-induced opening of the blood-brain barrier32. Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury33. Cerebral
About the Author: Edwin M. Nemoto, PhD, 1969 in Physiology, Biochemistry and Radiation Physics, Rutgers The State University mentor Dr. Harry M. Frankel. He studied the effects of hyperthermia on cerebral blood flow regulation and metabolism. Postdoctoral Fellowship (1969-1971) at Cardiovascular Research Institute, UCSF mentor, Dr. John Severinghaus. Studied CSF acid base balance. At the University of Pittsburgh 1972-2009, Department of Anesthesiology and Critical Care Medicine as Director of Anesthesia and CCM research Chair, Dr. Peter Safar, Neurosurgery and Radiology and studied brain circulation and metabolism in cardiac arrest, traumatic brain injury and stroke. In 2009 at the University of New Mexico, Director of Research of Neurosurgery, under Chair, Dr. Howard Yonas until June, 2020, semiretired and continues his research and work on his startup company, ShearIT, LLC. He hosted ISOTT meetings in Pittsburgh, PA in 1995 and again in Albuquerque, NM in 2019.
Eileen M. Harrison BSc, is a graduate in physiology from St Andrews University and was a freelance medical/pharmaceutical translator for a range of international companies until 2010.
She has been associated with ISOTT for over 35 years and since 2006 she has been Technical Editor of all the "Oxygen Transport to Tissue" volumes. In 2019 she also took on the role of Language Editor following the passing away of Laraine Visser.
Sally C. Pias is Associate Professor of Chemistry and Associate Chair of the Department of Chemistry at the New Mexico Institute of Mining and Technology (New Mexico Tech) in Socorro, NM, USA. She is a computational chemist with a research focus on oxygen transport modeling. She earned a PhD in Chemistry with specialization in Biochemistry from New Mexico State University (USA), then received postdoctoral training in computational chemistry at Stony Brook University (State University of New York, USA) as a Computing Innovation Fellow. Dr. Pias is an active member of the Bioenergetics, Mitochondria, and Metabolism Subgroup of the Biophysical Society. She is a past recipient of ISOTT's Melvin H. Knisely Award and a current member of the ISOTT Executive Committee. Dr. Pias coorganized the ISOTT 2019 meeting, along with Edwin Nemoto and Denis Bragin.
Denis E. Bragin is an Associate Professor of Translational Neurosciences at Lovelace Biomedical Research Institute and Adjunct Associate Professor at the Department of Neurosurgery University of New Mexico School of Medicine, Albuquerque, NM, USA. He is a biophysicist with a research focus on the circulation, oxygen supply, and metabolism of the brain under various pathological conditions. He earned a Ph.D. in Biology with specialization in Biophysics from the Voronezh State University (Russia), then received postdoctoral training in Neurosciences at Neuroscience Research Center (NWFZ), Charité Medical School, Humboldt University, Berlin (Germany) and Department of Neurosurgery, University of New Mexico School of Medicine (USA). Dr. Bragin is an active member of the American Heart/Stroke Association (AHA), the International Society of Cerebral Blood Flow and Metabolism (ISCBFM), the Society of Photo-Optical Instrumentation Engineers (SPIE) and the ISOTT. A Stroke Council of the AHA elected him as a Fellow of the American Heart Association (FAHA). Dr. Bragin co-organized the ISOTT 2019 meeting, along with Edwin Nemoto and Sally Pias.
David K. Harrison BSc, PhD (Uni. Dundee), Dr Med Habil (Uni Erlangen/Nuremberg), FIPEM was the Head of the Durham Unit of the Regional Medical Physics Department and Honorary Senior Lecturer in Medical Physics, Institute of Cellular Medicine, Newcastle University, UK until retiring from the NHS in 2009. He then became honorary Senior Scientific Consultant for Oroboros Instruments (Innsbruck, Austria), finally retiring in 2016.
He is author or co-author of over 130 publications, mainly in the field of blood flow and oxygen transport to tissue. He has been a member of ISOTT for over 35 years including President in 1996. Since 2004 he has been Scientific Editor of all of the "Oxygen Transport to Tissue" volumes.
Joseph C. LaManna, PhD is The Jeannette M. and Joseph S. Silber Professor for the Study of Brain Sciences in the Department of Physiology & Biophysics at Case Western Reserve University. He has been a member of ISOTT since 1974 and served as Past President of the Society (2009). He is the Series Editor of the ISOTT Proceedings. He has been involved in cerebrovascular research for 40 years. His research is concerned with brain metabolism, energy and cerebral blood flow, angiogenesis and neurodegeneration. The role of these mechanisms in tissue response to pathological insults (stroke, cardiac arrest and resuscitation, hypoxia) is being actively investigated. His recent research has centered on ketones, cerebral angiogenesis and the role of hypoxia-inducible factor-1 in physiological adaptation to hypoxia, neuroprotection and ischemic preconditioning. He has authored or co-authored over 200 research papers and review chapters.
