This book presents the evidence related to use of injectable biologics to provide faster and better healing for musculoskeletal lesions. It discusses the rationale of various approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage. On the basis of the most up-to-date literature, the authors explore both the potential and limitations of this minimally invasive and promising treatment.
The first section is devoted to the formulations and rationale of several injectable orthobiologics, while the second section presents current evaluation methods applied to specific joints and pathologies - from tendinopathies through non-unions to osteoarthritis - as well as the results. The third section explores future perspectives, such as pluripotent stem cells, gene therapy and the stimulation of intrinsic stromal cell niches.
Appealing to a broad readership this book is of interest to orthopedists, sports physicians, physiatrists and regenerative medicine experts.
About the Author: Giuseppe Filardo is the chief research advisor at the Rizzoli Orthopedic Institute for Translational and Applied Orthopedics, Bologna, and head of clinical research at the Ospedale Regionale of Lugano, Switzerland. His clinical research activities focus on the study of orthobiologics for the musculoskeletal system, particularly the development of minimally invasive treatments and the identification of the potential, indications and limits of the newly emerging regenerative approaches.
Bert Mandelbaum is double board certified in orthopedic surgery and orthopedic sports medicine. He received his MD degree from Washington University in St. Louis, then completed his residency at Johns Hopkins Hospital. He is widely recognized as one of the world's foremost experts in soccer injury. He has served as a head team physician on the men's and women's teams for multiple World Cups and Olympic Games.
George Muschler has become a respected expert in reconstructive surgery for arthritis, failed joint replacements, treatment of fractures and limb deformities. He is recognized internationally as a leader in skeletal reconstruction, bone regeneration, and fracture repair. A member of the Cleveland Clinic Taussig Cancer, he is a pioneer in the development of collaborative interdisciplinary programs and research teams in the area of tissue engineering and regenerative medicine.
Scott Rodeo is a clinician scientist at the Hospital for Special Surgery (HSS), with appointments in the Department of Orthopedics and the Research Department. He is a Professor of Orthopedic Surgery at Weill Cornell Medical College and Co-Chief Emeritus of the Sports Medicine Service at the Hospital for Special Surgery. He specializes in sports medicine injuries of the knee, shoulder, ankle and elbow and performs arthritis surgery on the knee and shoulder, including joint replacement surgery.
Norimasa Nakamura is a Professor at the Institute for Medical Science in Sports at Osaka Health Science University and the Global Center for the Medical Engineering and Informatics at Osaka University. He is also an orthopedic surgeon at the Osaka University Hospital, specializing in arthroscopic surgery and sports medicine. His research focuses on joint-tissue repair, particularly the regeneration of cartilage, ligament, and meniscus. He has published over 150 peer reviewed scientific papers.
