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Novel Approach of Formulation of Doxorubicin Drug Conjugate

Novel Approach of Formulation of Doxorubicin Drug Conjugate


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About the Book

In the present study a series of Cu (II) complexes of Schiff base molecular adducts of doxorubicin have been synthesized and characterized by analytical, molar conductance, IR electronic magnetic susceptibility and powder XRD measurements and screened for various biological activities (antioxidants, and cytotoxicity). In all the Cu (II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non- electrolytic in nature. Based on the electronic and magnetic data, an distorted octahedral geometry is ascribed for all the copper (II) complexes. All Cu (II) complexes showed considerable anticancer activity against MCF-7 cell lines and more pronounced antioxidant activity lines and more pronounced antioxidant activity in the presence of DPPH. The newly synthesized title compounds were evaluated for their MCF-7 cell growth inhibition, the results revealed that all the tested compounds possess inhibitory effects on the growth of MCF-7 cancer cells. Compound 3 showed the highest inhibition activity against MCF-7 cell line (IC50 7.21 ± 0.1 μg/ml) among all tested Compounds.


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Product Details
  • ISBN-13: 9786206142645
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: LAP Lambert Academic Publishing
  • Height: 229 mm
  • No of Pages: 52
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 6206142647
  • Publisher Date: 02 Feb 2023
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 141 gr


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