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Natural & synthetic 1-Phenylnaphthalene lignans

Natural & synthetic 1-Phenylnaphthalene lignans


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About the Book

1-Phenylnaphthalene and Pericarbonyl lactone lignans are synthesized by green chemistry and the lignans having similar 1-Phenylnaphthalene skeleton are extracted from two plants-Ruta graveolens Linn. and Jatropha gossypifolia Linn using soxhlet assembly.These natural and synthetic lignans were then tested for their immunomodulatory potential. Starting with β-benzoyl propionic acid and aryl aldehydes, α-arylidine-γ-phenyl-∆,β,γ-butenolides were synthesized. The lactone ring of butenolides is opened to get the keto acid i.e. α-arylidine-β-benzoyl propionic acid. Cyclization of above keto acid as well as its derivatives with sulphamic acid catalyst under microwave radiation ultimately lead to 1-Phenylnaphthalene systems. The immunomodulatory activity of the 1-Phenylnaphthalene systems is studied by the two methods-"Spleen cell proliferation" and "Effect on serum immunoglobulins". It is found to be quite significant in both synthetic compounds as well plant extracts. The findings suggest that 1-Phenylnaphthalene lignans can positively modulate the immunity of the host.


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Product Details
  • ISBN-13: 9783659347269
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 10 mm
  • Weight: 322 gr
  • ISBN-10: 3659347264
  • Publisher Date: 02 Mar 2013
  • Height: 229 mm
  • No of Pages: 180
  • Series Title: English
  • Sub Title: Immunomodulation
  • Width: 152 mm


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