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Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy


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About the Book

Part I. Mechanism of tumor cell resistance to cytotoxic apoptosis drugs: Innate versus induced 1. Molecular pathway of apoptosis 2. Molecular anti-apoptotic pathways in cancer 3. Genetic mechanisms that regulate resistance 4. Oncogenesis and tumor cell resistance 5. Molecular heterogeneity of various cancers and cancer stem cells in resistance 6. Molecular signature profiles of resistance in cancers Part II. Dominant pathways and gene products that regulate resistance 7. Resistant targets for apoptosis 8. Autocrine and Paracrine factors 9. Oncogenes 10.Tumor micro environment Part III. Selective agents that target resistant mechanisms: Direct and indirect 11. Proteasome inhibitors 12. Chemicals: free and encapsulated in nanoparticles 13. Receptor agonists and antagonists 14. Antibodies
About the Author: Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals. In his career, he's published over 450 papers and reviews, and he's also edited two books with Springer in the past. For more information, please see the CV attached herewith.


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Product Details
  • ISBN-13: 9781461470694
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Depth: 19
  • Height: 231 mm
  • No of Pages: 260
  • Series Title: Resistance to Targeted Anti-Cancer Therapeutics
  • Sub Title: Targeted Therapies to Reverse Resistance
  • Width: 155 mm
  • ISBN-10: 1461470692
  • Publisher Date: 27 Apr 2013
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 20 mm
  • Weight: 621 gr


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