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Molecular Determinants of Head and Neck Cancer

Molecular Determinants of Head and Neck Cancer


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About the Book

Chapter 1: Overview: The Pathobiology of Head and Neck Cancer

Chapter 2: Human papillomavirus (HPV)-positive head and neck cancer and the Wnt signaling pathway.....Theodoros Rampias and Amanda Psyrri

Chapter 3: EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer.....Hanqing Liu, Jennifer R. Cracchiolo, Tim N. Beck, Ilya G. Serebriiskii, and Erica A. Golemis

Chapter 4: The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma.....Tanguy Y. Seiwert, Tim N. Beck and Ravi Salgia
Chapter 5: Insulin-like Growth Factor-1 Receptors in Head and Neck Cancer.....Steven A. Rosenzweig and Casey O. Holmes

Chapter 6: The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma......Jason D. Howard and Christine H. Chung

Chapter 7: Jak/STAT Signaling in HNC.....Bhavana S. Vangara and Jennifer R. Grandis

Chapter 8: TGFβ regulates EMT in head and neck cancer.....Jill M. Neiman and Xiao-Jing Wang

Chapter 9: p53 in Head and Neck Cancer.....Jong-Lyel Roh and Wayne M. Koch

Chapter 10: DNA damage proteins and response to therapy in head and neck cancer.....Ranee Mehra and Ilya G. Serebriiskii

Chapter 11: Hypoxia and radioresistance in head and neck cancer.....Peiwen Kuo and Quynh-Thu Le

Chapter 12: The Wnt -catenin Signaling Circuitry in Head and Neck Cancer.....Rogerio M. Castilho and J. Silvio Gutkind

Chapter 13: Sequencing HNC: Emergence of Notch Signaling......Curtis R. Pickering, Thomas J. Ow, Jeffrey N. Myers

Chapter 14: Gene Expression in HNC.....Michael F Ochs and Joseph A Califano

Chapter 15: Epidemiology of HPV in Head and Neck Cancer; variant strains, discrete protein function.....Camille C.R. Ragin, Jeffrey C. Liu

Chapter 16: Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck.....Barbara Burtness


About the Author:

Barbara Burtness, M.D. is Associate Director for Clinical Research at the Fox Chase Cancer Center. She is also a co-leader of the Keystone Program in Head and Neck Cancer. As Chair of the Head and Neck Committee in the Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer.

Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer at the Fox Chase Cancer Center. She is also the Co-Leader of Developmental Therapeutics and Co-Leader of the Head and Neck Cancer Keystone at Fox Chase. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes.


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Product Details
  • ISBN-13: 9781493944897
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: Softcover reprint of the original 1st ed. 2014
  • Language: English
  • Returnable: Y
  • Spine Width: 20 mm
  • Width: 156 mm
  • ISBN-10: 1493944894
  • Publisher Date: 03 Sep 2016
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 362
  • Series Title: Current Cancer Research
  • Weight: 575 gr


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