Um die Funktionalität eines Proteins vollständig zu erfassen, muss man seine Wechselwirkungen mit anderen Proteinen verstehen. Alle dafÃ1/4r relevanten Proteindomänen (SH2, SH3, PDZ, WW, PTB, EH, PH und PX) erfasst dieses in seiner Art einmalige Nachschlagewerk. Der Stoff wurde sinnvoll ausgewählt, geordnet und mit Verweisen versehen, sodass man gewÃ1/4nschte Informationen schnell findet. Ein spezielles Kapitel stellt Hilfsmittel und relevante Datenbanken vor, die kostenlos aus dem Internet heruntergeladen werden können. Unentbehrlich fÃ1/4r alle, die Wechselwirkungen zwischen Proteinen in vivo oder in silico (am Computer) untersuchen oder sich mit Proteomik beschäftigen.
About the Author: Gianni Cesareni is a Full Professor of Genetics at the University of Rome Tor Vergata (Italy). After obtaining a degree in physics at the University of Rome La Sapienza he spent three years in Cambridge in the laboratory of Sidney Brenner. He then moved to the EMBL in Heidelberg where he led a group working on the mechanisms controlling plasmid DNA replication. Since 1989 he teaches and works in Rome. He is interested in the interplay between specificity and promiscuity in the protein interaction network mediated by protein recognition modules.

Mario Gimona is laboratory head at the Consorzio Mario Negri Sud in Santa Maria Imbaro (Italy) and reader for molecular cell biology at the University of Salzburg (Austria). He was born in Salzburg where he also received his degrees in genetics and biochemistry, after completing his Ph.D. work in the lab of Vic Small at the Austrian Academy of Sciences. Following his post-doctoral time at the CSHL, New York (USA) with David Helfman he set up his own laboratory in Salzburg at the OeAW in 1996. His research interests revolve around the linguistic variation of functional protein modules and their role in the regulation of the actin cytoskeleton.

Marius Sudol has been an Associate Professor at the Mount Sinai School of Medicine in New York since 1995. He was instrumental in the delineation and characterization of one of the smallest protein modules, the WW domain. His work also implicated the WW domain in signaling pathways underlying several human diseases including Alzheimer's disease, hypertension and cancer. He earned a Ph.D. at The Rockefeller University in New York in 1983 and stayed at his Alma Mater as a postdoctoral fellow and faculty member until his move to Mount Sinai. Dr.Sudol has published 95 research articles and is credited as inventor on two biotechnology patents.

Michael B. Yaffe is Associate Professor of Biology at the Center for Cancer Research, Massachusetts Institute of Technology. He earned his MD and PhD degrees at Case Western Reserve University, and did residency training in general surgery, trauma and critical care medicine at Harvard Medical School. He was a post-doctoral fellow in Cell Biology at Harvard under Lewis C. Cantley, where he remained as junior faculty until moving to MIT in 2000. He is interested in signal transduction, protein phosphorylation, and phosphopeptide-binding domains, with a focus on cell cycle control, DNA damage responses, and inflammation.

All editors are members of the Protein Module Consortium, a world-wide organization to support researchers interested in protein modules.