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Melt Extrusion

Melt Extrusion


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About the Book

Melt Extrusion in Drug Delivery: Three Decades of Progress.- Twin Screw Extrusion for Pharmaceutical Processes.- Properties and Applications of Polyvinyllactam Polymers.- Properties and Applications of Hypromellose Acetate Succinate (HPMCAS) for Solubility Enhancement Using Melt Extrusion.- Cellulose Ethers for Extrusion Applications.- Properties and Applications of Polyethylene Oxide and Ethylcellulose for Tamper Resistance and Controlled Drug Delivery.- Formulation Development of Amorphous Solid Dispersions Prepared by Melt Extrusion.- Non-Sink In Vitro Dissolution Testing of Amorphous Solid Dispersions.- Manufacture of Pharmaceutically Relevant Materials by Mechanochemistry Using Twin Screw Extrusion.- Melt Extruded Controlled Release Dosage Forms.- Excipient/API Melt Processing via Injection Molding.- Devices and Implants Prepared Using Hot Melt Extrusion.- Solid Lipid Extrusion.- Formulation, Bioavailability and Manufacturing Process Enhancement: Novel Applications of Melt Extrusion in Enabling Product Development.- Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process.- Hot-Melt Extrusion Process Design Using Process Analytical Technology.- Consistency of Pharmaceutical Products: An FDA Perspective on Hot-melt Extrusion Process.- Melt Extrusion: A Commercial Perception to Practicality.- Future Trends.


About the Author:

Dr. Michael A. Repka is Chair and Professor of the Department of Pharmaceutics at The University of Mississippi, as well as Director of the Pii Center for Pharmaceutical Technology. Dr. Repka joined the faculty at Ole Miss after receiving his Ph.D. from The University of Texas College of Pharmacy and founded a pharmaceutical research/development company that specializes in drug delivery. His research interests include oral transmucosal and transdermal/trans-nail delivery systems, as well as other novel dosage forms. Many of these systems are directed toward the solubilization and delivery of poorly soluble bioactives via Hot Melt Extrusion technology, which is a primary focus of his research. Dr. Repka's most important scientific accomplishments involve the advancement of melt extrusion technology. He has established himself as an expert in this major pharmaceutical processing field through his numerous peer-reviewed publications, presentations and scientific talks.

Dr. Nigel Langley is currently Head of Marketing and Technical Sales at BASF Corporation where he is responsible for the promotion and technical support for BASF's Pharmaceutical excipients and APIs to the Pharmaceutical Industry in North America. He has a strong interest in solubilization including Hot Melt Extrusion. He received his PhD in Liquid Crystals from Hull University, UK and an MBA from Leeds University, UK. Prior to joining BASF he worked for Croda International in UK, Japan and USA.

Dr. James DiNunzio is currently an Associate Principal Scientist in the Formulation & Basic Pharmaceutical Sciences Group at Merck & Co., Inc. where he serves as a member of the Hot Melt Extrusion Technology Development Team. He received his Ph.D. in Pharmacy from the University of Texas at Austin and holds M.S. and B.S. in Chemical Engineering from Columbia University and SUNY Buffalo, respectively. Prior to joining Merck, he served as Senior Scientist at Hoffmann-La Roche where he was responsible for the development of enabled formulations using hot melt extrusion. He has also held scientific positions at PharmaForm, LLC and Forest Laboratories. With over seven years of industry experience, his research interests include formulation design of amorphous dispersions, development of controlled release products using melt extrusion, continuous manufacturing and engineering of directly shaped drug products.


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Product Details
  • ISBN-13: 9781461484318
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Depth: 32
  • Height: 234 mm
  • No of Pages: 474
  • Series Title: Aaps Advances in the Pharmaceutical Sciences
  • Sub Title: Materials, Technology and Drug Product Design
  • Width: 156 mm
  • ISBN-10: 1461484316
  • Publisher Date: 11 Oct 2013
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 27 mm
  • Weight: 906 gr


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