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Marfan Syndrome

Marfan Syndrome


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About the Book

Historical Introduction The Marfan Syndrome: From Clinical Delineation to Mutational Characterization, a Semiautobiographic Account VictorA. McKusick l n 1876, E. Williams, an ophthalmologistin Cincinnati, Ohio, described ectopia lentis in a brother and sister who were exceptionally tall and had been loosejointed from birth. I Although there is a Williams syndrome that has aortic manifestations (supravalvar aortic stenosis), the name Williams was never associated with the disorder we now call Marfan syndrome. The reason is clear: Williamswas geographically removed from the leading medical centers and published in the Transactions of the American Ophthalmological Society; surely his report attracted little attention and the non-ocular features were not emphasized. 2 The case report that brought the disorder to attention was provided by a prominent Pari- sian professor of pediatrics, Antoine Bernard-Jean Marfan (1858-1942), who did much to establish pediatrics as a specialty in France and elsewhere. He was the author of widely read textbooks and monographson pediatrictopics and waseditor of Le Nourrisson for a great many years. In addition to the syndromeunder discussion here, his name is often attached to "Marfan's law" (that immunity to pulmonary phthisis is conferred by the healing of a local tuberculous 3 lesion) and Marfan's subxiphoid approach for aspiratingfluid from the pericardial sac. (Please pardon my use of the possessive form of the eponym in these two instances!) Pictures of Marfan (Fig.


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Product Details
  • ISBN-13: 9780306482380
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2004
  • Language: English
  • Returnable: Y
  • Spine Width: 14 mm
  • Weight: 557 gr
  • ISBN-10: 030648238X
  • Publisher Date: 02 Nov 2004
  • Binding: Hardback
  • Height: 234 mm
  • No of Pages: 218
  • Series Title: Medical Intelligence Unit (Unnumbered)
  • Sub Title: A Primer for Clinicians and Scientists
  • Width: 156 mm


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