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Les microARN sériques comme biomarqueurs de l'infection tuberculeuse active et latente

Les microARN sériques comme biomarqueurs de l'infection tuberculeuse active et latente


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About the Book

Les profils d'expression des microARN dans les fluides corporels peuvent être utilisés comme biomarqueurs non invasifs, rapides et précis pour diverses maladies. L'étude vise à identifier les modèles de signatures de microARN pour le diagnostic de la tuberculose et à évaluer l'importance des antécédents génétiques d'un patient sur la composition de la signature et la performance du diagnostic. Des participants consentants atteints de tuberculose active, de tuberculose active co-infectée par le VIH, d'infection tuberculeuse latente, d'autres infections pulmonaires et des individus sains ont été recrutés en Italie et en Afrique de l'Est. Une signature de 15 miRNA a été observée pour différencier les individus sains de ceux atteints de PTB avec une précision diagnostique de 82% dans le RVM et 77% dans le modèle de classification logistique. L'analyse basée sur le bagage génétique a identifié une signature de 10 miRNAs qui était spécifique aux Européens avec une précision diagnostique de 83% dans le RVM, et de 81% dans le modèle logistique. Tandis qu'une signature de 12 miRNA était spécifique à la cohorte africaine et l'exactitude diagnostique a augmenté jusqu'à 95% et 100% dans le RVM et le modèle logistique, respectivement.Les miRNA sont un candidat diagnostique prometteur pour la TB, donc une évaluation prospective supplémentaire de ce diagnostic semble justifiée pour les scientifiques.


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Product Details
  • ISBN-13: 9786205394533
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 80
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6205394537
  • Publisher Date: 26 Nov 2022
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 181 gr


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Les microARN sériques comme biomarqueurs de l'infection tuberculeuse active et latente
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Les microARN sériques comme biomarqueurs de l'infection tuberculeuse active et latente
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