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I Domains in Integrins

I Domains in Integrins


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About the Book

In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.
This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.


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Product Details
  • ISBN-13: 9780306478369
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2003 ed.
  • Language: English
  • Returnable: Y
  • Spine Width: 19 mm
  • Width: 158 mm
  • ISBN-10: 0306478366
  • Publisher Date: 31 Jul 2003
  • Binding: Hardback
  • Height: 242 mm
  • No of Pages: 186
  • Series Title: Molecular Biology Intelligence Unit
  • Weight: 489 gr


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