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Gaba and Sleep

Gaba and Sleep


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About the Book

Section I - Basic Physiology and Pharmacology.- The New Pharmacology and Physiology of the GABA System: Function of GABAA and GABAB Receptor Subtypes.- Development of Subtype Selective GABAA Receptor Compounds for the Treatment of Anxiety Disorders, Primary and Comorbid Insomnia, and Epilepsy.- Distribution of GABAA Receptor Subunits in the Human Brain.- Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics.- Section II. Sleep Science and Circuitry.- Sleep and its Modulation by Drugs that Affect GABAA Receptor Function.- Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System.- Function of GABAB and GABAC Receptors in the Regulation of Basic and Higher Integrated Sleep-Waking Processes.- Interaction between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness.- GABAergic Modulation of Pontine Cholinergic and Noradrenergic Neurons of Rapid Eye Movement (REM) Sleep Generation.- Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine and Tegmental Nuclei (LDT-PPT) in the Promotion of REM Sleep.- GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum - the REM Sleep Induction Site - in the Modulation of Sleep/Wake States.- The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep.- Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms.- GABA Involvement in the Circadian Regulation of Sleep.- Section - III. Neurotherapeutics.- Pathophysiology of Sleep Disorders.- Insomnia: Differential Diagnosis and Current Treatment Approach.- Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients.- Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia.- Indiplon.- Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia


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Product Details
  • ISBN-13: 9783034807401
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Edition: 2010 ed.
  • Language: English
  • Returnable: N
  • Spine Width: 26 mm
  • Weight: 766 gr
  • ISBN-10: 3034807406
  • Publisher Date: 23 Sep 2014
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 486
  • Series Title: English
  • Sub Title: Molecular, Functional and Clinical Aspects
  • Width: 156 mm


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