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Fremdkörpersarkome

Fremdkörpersarkome


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About the Book

Die AuslOsung von Fremdkorpersarkomen ist eine neue, von bekannten cancerogenen Faktoren unabhangige Krebsursache. Sie ist ein Beispiel fur die bislang kaum systematisch bearbeitete "unspezifische Geschwulstaus- lOsung". Die Vielfalt der fur diese Blastogenese bedeutsamen exogenen und endogenen Faktoren (Implantatgroge, Oberflachenbeschaffenheit, Porositat, Verweildauer, Gewebsvertraglichkeit, Korperregion, Gewebeart, Tierstamm, Tierart u. a. ) sind durch die unterschiedliche Quantitat des gebildeten pra- sarkomatosen Gewebes zu interpretieren. Die Beobachtung, dag neben Metallen und Kunststoffen auch heteroplastische Knochentransplantate Sar- kome auslOsen konnen, dag sie auch mit schwer resorbierbaren Stoffen wie Catgut und Gewebeklebern auszulosen sind, beinhaltet fur Chirurgen das Problem, ob nicht nach Fremdkorperimplantaten, Organ-und Gewebetrans- plantationen mit einer Geschwulstauslosung zu rechnen ist. Eine Zusammen- stellung der klinischen Beobachtungen von Sarkomen nach met allis chen und nichtmetallischen Implantaten zeigt, dag soIehe Ergebnisse auch fur den Menschen bedeutsam sind. Sarkome in Operationsnarben und Prothesen- sarkome als Beispiel von Narbensarkomen erganzen diese Synopsis und geben Anhaltspunkte fur die Begutachtung von Geschwulsten nach Traumen allgemein. Krebsprophylaktische Magnahmen bei der Implantation allo- plastischer Fremdkorper konnen auf Grund solcher Untersuchungen heute bereits festgelegt werden. Aufgabe dieser Schrift ist es, die verstreute Literatur und Einzelergeb- nisse zusammenfassend darzustellen, offene Probleme durch eigene Ver- suchsergebnisse zu erganzen und die vielfaltigen Ansatzpunkte fur eine sinn volle Fortfuhrung dieser Forschung aufzuzeigen. Die Interpretation der vorliegenden Ergebnisse in einer synoptischen Arbeitshypothese, nach welcher die Fremdkorpersarkome als Narbenkrebs anzusehen sind, erklart die wider- spruchliche Vielfalt an klinischen und experimentellen Beobachtungen. Bonn-Bad Godesberg, Juli 1970 GERHARD OTT Inhaltsverzeichnis 1 I. Einleitung . . . . . II. Gesdtichtlicher Riidi. blidi.


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Product Details
  • ISBN-13: 9783642867743
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Binding: Paperback
  • Height: 234 mm
  • No of Pages: 120
  • Series Title: Experimentelle Medizin, Pathologie Und Klinik
  • Weight: 245 gr
  • ISBN-10: 364286774X
  • Publisher Date: 19 Mar 2012
  • Edition: Softcover reprint of the original 1st ed. 1970
  • Language: German
  • Returnable: Y
  • Spine Width: 7 mm
  • Width: 156 mm


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