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Formulation Et Évaluation de Comprimés Auto-Émulsifiés d'Atorvastatine

Formulation Et Évaluation de Comprimés Auto-Émulsifiés d'Atorvastatine


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About the Book

En raison de la faible solubilité et absorption des médicaments, de nombreux candidats médicaments ne répondent pas aux attentes. Les méthodes d'administration de médicaments auto-émulsifiants augmentent la solubilité et la biodisponibilité des médicaments peu solubles. Lorsque les SEDDS sont ajoutés à une phase aqueuse et mélangés doucement, de fines émulsions huile-dans-eau se forment. Les SEDDS se présentent sous forme de capsules de gélatine molle ou dure pour l'administration orale et forment des émulsions huile-dans-eau fines et stables. Les SEDDS sont principalement fabriqués sous forme de formulations liquides, qui présentent une stabilité et une mobilité médiocres, une faible charge médicamenteuse, un nombre limité d'options de forme posologique, une précipitation irréversible du médicament et de l'excipient, et une proportion élevée (30-60%) de surfactants qui pourraient irriter le système gastro-intestinal. Le SEDDS solide a été étudié pour éviter les problèmes du SEDDS liquide. L'adsorption de formulations liquides auto-micro-émulsionnées sur des supports solides est l'une des meilleures façons de créer des poudres à écoulement libre pour la compression en forme de comprimé (SMET).


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Product Details
  • ISBN-13: 9786205610664
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 80
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6205610663
  • Publisher Date: 23 Jan 2023
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 181 gr


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