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Exploring Drug Delivery to the Peritoneum

Exploring Drug Delivery to the Peritoneum


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About the Book

The Peritoneal cavity (PC) is key metastatic site for intra-abdominal malignancies (e.g. GI tract and rectal cancer). PC site can be used to target several other diseases where lymphatic drug delivery is desired without dumping large amount of drug. Till recently, it was thought that treatment with curative intent was impossible but that was challenged by the introduction of cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) and PIPAC (pressurized intraperitoneal aerosol chemotherapy). Recently, a growing number of preclinical and clinical studies advocate intraperitoneal (IP) chemotherapy as an alternative post-operative therapy cancer. Although their effectiveness has been proven both experimentally and clinically, there is still little understanding on role of drug delivery systems (DDS) for targeting drugs to IP cavity. Nevertheless, IP chemotherapy has not yet been adopted widely in practice for the ovarian cancer treatment, and there are several challenges in IP drug delivery.There are two main challenges one posed by IP cavity where the residence time of a small molecular weight drug (In summary, challenges like delivery to IP cavity, tumor or organ specific targeting, efficient tissue penetration, optimal cellular uptake and intracellular residence of a drug, biocompatibility, toxicity etc can be easily solved by smartly designing functional drug delivery systems (both nano and micro). Nanotechnologies have always fascinated human since several decades and are now widely explored in biomedical field. Diverse types of nanoparticles are being explored around the world, some examples include biodegradable nanoparticles, green nanoparticles, polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, graphene, carbon nanotubes and several others. Now a day's nanoparticles are gaining interest for drug targeting of chemotherapeutic drugs, immunotherapy and gene delivery. Whereas microparticles can be explored for delayed drug delivery to peritoneal cavity due to relatively slowly removal from IP fluid. Hydrogels or other adhesive drug delivery may help to enhance peritoneal adhesions; thereby maintaining the balance between benefit-and-risk. Overall, drug delivery systems are key in IP targeting. That means drug delivery specialist and clinician needs to be connected to get best out of this route of drug administration.Present books, is a link between pharmaceutical scientist (delivery formulators), clinicians, toxicologist and regulatory experts. This book also provides new perspective to researchers to divert or guide their research in optimal way. Exploring Drug Delivery to the Peritoneum serves as a platform for upcoming technologies especially in medical devices sector to face up and show potential in delivering drug. It is a chance for commercial partners like insurance companies and pharma industry to explore in this direction.
About the Author: Ranjita Shegokar holds a Ph.D. degree in Pharmaceutical Technology from the SNDT University, India, and has been a postdoctoral researcher in the Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics at the Free University of Berlin, Germany. For the last many years she has been working with various multinational pharmaceutical companies in technical/R&D leadership roles. Currently, she serves as a Chief Scientific Officer (CSO) at Capnopharm GmbH, Germany. She has authored several research articles, book chapters, and presented her research in many national/international conferences. She has filed multiple patent applications in the area of drug delivery and targeting. Besides that, she has edited multiple trending books in the area of pharmaceutical nanotechnology and drug delivery aspects. For her research, she has received numerous prestigious national and international awards among them include recently received prestigious German Innovation Award 2022. Her areas of interest include polymeric nanoparticles, nanocrystals, lipid nanoparticles (SLNs/NLCs), nanoemulsions, cancer drug targeting and the role of excipients in delivery systems (www.ranjitas.com).


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Product Details
  • ISBN-13: 9783031316937
  • Publisher: Springer International Publishing
  • Publisher Imprint: Springer
  • Height: 234 mm
  • No of Pages: 480
  • Spine Width: 16 mm
  • Width: 156 mm
  • ISBN-10: 3031316932
  • Publisher Date: 04 Dec 2023
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Weight: 585 gr


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