This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic.

Prof. Rosario Pivonello is Associate Professor of Endocrinology at "Federico II" University of Naples, Italy. In 2003, he received a PhD in Neuropsychopharmacology and Toxicology at "Federico II" University, and in 2005 a PhD in Internal Medicine (Basic and Clinical Endocrinology) at Erasmus University, in Rotterdam, The Netherlands, focusing his research on the role of dopaminergic system in pituitary and adrenal tumors. His major clinical interest and scientific research production include pituitary and adrenal diseases, with a focus on Cushing's syndrome, for which he is recognized as expert by the scientific community. He is principal investigator of international multicenter studies on Cushing's syndrome, acromegaly and adrenal diseases, and of national research projects in endocrinology, funded by the Italian Ministry of University and Research (MIUR) and Italian Ministry of Health (MoH).

In the last decade, his clinical and research interests include the study of andrology and sexual medicine. In 2011 he pursued a Master in Andrology and Sexual Medicine at University of Florence, Italy and in 2016 a Master in Andrology and Seminology at "La Sapienza" University of Rome, Italy. He is Director of the "FERTISEXCARES", Centre of Andrology and Medicine of Male and Female Reproduction and Sexuality (Excellence Centre of the Italian Society of Andrology and Sexual Medicine - SIAMS) at University Hospital "Federico II", and head of the homonym Intra-departmental program, and head of the Andrology program within the UNESCO Chair "Health Education an Sustainable Development", "Federico II" University (Chair coordinator Prof. Annamaria Colao). His most recent clinical and research activity in the field of reproduction and fertility includes a national multicenter observational study (GONADIS) on gonadal status and reproductive and sexual function in patients of both sexes with pituitary and adrenal disorders, of which he is the coordinator, and regional research projects in andrology, funded by Campania Regional Government, of which he is the principal investigator.

He got several national and international Committee Membership and Editorship. Presently, he is member of the Executive Committee of the European Neuroendocrine Association (ENEA) (2016 to date). He is coordinator of the Scientific Committee (2018 to date) and has been coordinator of the "Drugs" Committee (2017-2019), member of Scientific Committee (2010-2012), and member of Executive Committee (2012-2016) in the Italian Society of Andrology and Sexual Medicine (SIAMS). In the Italian Society of Endocrinology (SIE), he is member of the Scientific Committee (2017 to date) and coordinator of the SIE Club "Endocrinology and Metabolism of Sport and Physical Exercise" (2018 to date). He is Associate Editor for Frontiers in Endocrinology, section of "Pituitary Endocrinology" (2017 to date), and Editorial Board Member for the International Journal of Molecular Sciences, section "Molecular Endocrinology and Metabolism" (2019 to date).

Dr.Evanthia Diamanti-Kandarakis is emeritus professor of Internal Medicine & Endocrinology and Chairman of the Department of Εndocrinology & Diabetes at HYGEIA HOSPITAL in Athens. She received her MD from Medical School of Athens and her PhD in experimental Endocrinology on the effects of androgens in hypophysectomised rats, from the same University. Her training in Internal Medicine took place in England (1974-1980), and in Endocrinology- Diabetes, Metabolism & Obesity in USA (1980-1986). Her research interests have focused for the last 25 years on clinical, molecular and environmental aspects of metabolic & hormonal abnormalities in obesity Diabetes and Polycystic ovarian syndrome. This work has generated 187 publications with approx. 17000 citations, classifying her among the 27 best Greek scientists worldwide and the first Greek woman endocrinologist among them. She has been awarded as the best teacher in endocrinology in Greece for three consecutive years, in 2016, 2017 and 2018, after undisclosed vote of young endocrinologists in Greece. On 22 May 2017 at the European Congress of Endocrinology in Lisbon, the European Society of Endocrinology awarded her with the "HORMONE MEDAL of European Endocrinology Societies" for her outstanding contribution in the field of Endocrinology and Metabolism, among 49 candidates from all European Endocrinology societies. She is the inspirator and organizer of the COMBO ENDO original training international course, taking place yearly in Athens Greece. Dr. Diamanti-Kandarakis has been invited by the international academic community as a speaker and Tutor and has given more than 250 lectures, literally around the globe (Europe, Asia, Africa, North & South America).