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Entwicklung analytischer Methoden für Rosuvastatin

Entwicklung analytischer Methoden für Rosuvastatin


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About the Book

Für die Analyse von Rosuvastatin Calcium wurde ein spezifisches und unkompliziertes HPLC-Verfahren entwickelt und validiert. Rosuvastatin Calcium gehört zur Familie der Statine, einem Reduktaseinhibitor für 3-Hydroxy-3-methylglutaryl-Coenzym A (HMG-CoA). Das Medikament wird zur Behandlung von Bluthochdruck und ischämischer koronarer Herzkrankheit eingesetzt. Es wird auch zur Behandlung von Dyslipidämie und zur Senkung des "schlechten Cholesterinspiegels" eingesetzt. Die Technik wurde auf einer C18-Säule (250 4,6 mm 1.d; 5) im isokratischen Modus mit der mobilen Phase Acetonitril und Wasser im Verhältnis 75:25 v/v durchgeführt. Die Wellenlänge beträgt 242 nm und die Flussrate 0,6 Milliliter pro Minute. Die Linearität wurde zwischen 10 und 60 µg/ml mit einem Korrelationskoeffizienten von 0,9998 festgestellt. Das Medikament hat eine Retentionszeit von 3,643. Da die vorgeschlagene Methode einfach, schnell, genau, präzise und wiederholbar ist, kann sie für die routinemäßige Qualitätskontrolle von Rosuvastatin sowohl in reiner Form als auch in Tablettenform verwendet werden.


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Product Details
  • ISBN-13: 9786206102168
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 145 gr
  • ISBN-10: 6206102165
  • Publisher Date: 18 Jun 2023
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm


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