full screen
Home > General > Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion
Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion

Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
About the Book

Diabetes Mellitus is a metabolic disorder associated with insulin deficiency, which not only affects the carbohydrate metabolism but also is associated with various central and peripheral complications. Chronic hyperglycemia during diabetes mellitus is a major initiator of diabetic microvascular complications like retinopathy, neuropathy, nephropathy (Sheetz & King, 2002). Glucose processing uses a variety of diverse metabolic pathways. Chronic hyperglycemia can induce multiple cellular changes leading to metabolic disorders. The central nervous system (CNS) neurotransmitters play an important role in the regulation of glucose homeostasis. These neurotransmitters mediate rapid intracellular communications not only within the central nervous system but also in the peripheral tissues. They exert their function through receptors present in both neuronal and non neuronal cell surface that trigger second messenger signaling pathways (Julius, et al., 1989).

Neurotransmitters have been reported to show significant alterations during hyperglycemia resulting in altered functions causing neuronal degeneration (Kaur, et al., 1999). Neurochemical and neuro-imaging evidences have been reported to show regionally selective sympathetic denervation in diabetic neuropathy (Goldstein, et al., 2002). The changes in the brain monoamines during experimental diabetes have been reported. The serotonin content is doubled in the hypothalamus with no apparent alteration of its metabolite 5-hydroxy indole acetic acid (5-HIAA) levels, suggesting a reduced release. In the brain stem, serotonin and dopamine with the relative metabolites 5-HIAA and dihydroxyphenylacetic acid (DOPAC) are significantly reduced whereas noradrenaline is markedly increased (Chen, 1992). Insulin deficiency is the major factor involved as a trigger of the monoaminergic changes in the diabetic brain; Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in the brain regions of rats (Shimzu, 1991; Chen & Yang, 1991). The effects of streptozotocin (STZ)-induced diabetes on dopamine and serotonin release in striatum revealed that striatal dopamine release increased in acute diabetic state and this release depleted during the chronic state.


Best Sellers



Product Details
  • ISBN-13: 9781805251477
  • Publisher: Independent Author
  • Binding: Paperback
  • Language: English
  • Spine Width: 8 mm
  • Width: 152 mm
  • ISBN-10: 1805251473
  • Publisher Date: 21 Mar 2023
  • Height: 229 mm
  • No of Pages: 142
  • Weight: 267 gr


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion
Independent Author -
Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Dopamine receptor gene expression in streptozotocin induced diabetic rats and its role in insulin secretion

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Booksbay (the "CRR Service").


    By submitting any content to Booksbay, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Booksbay (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Booksbay a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Booksbay may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Booksbay's sole discretion. Booksbay reserves the right to change, condense, withhold publication, remove or delete any content on Booksbay's website that Booksbay deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Booksbay does not guarantee that you will have any recourse through Booksbay to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Booksbay reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Booksbay, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Booksbay, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!