Advancing the Research Agenda for DSM-V, Diagnostic Issues in Dementia comprises nine chapters with research suggestions for consideration for the upcoming DSM-V process, reflecting the nascent effort toward a new diagnostic nomenclature in the still rapidly evolving field of dementia.

Here, 18 experts provide critical pieces of the dementia diagnostic story: - The all-important neuropathological criteria of Alzheimer's disease and the aging brain; current epidemiologic literature and the challenges of making even minor changes in the general definition of dementia; and a scholarly review of the diagnostic nomenclature across the existing criteria, with numerous critiques and suggestion for future research- The growing evidence for mild cognitive impairment as an identifiable entity suitable for inclusion in DSM-V; the current neuropsychological profiling that serves as the centerpiece of the diagnostic criteria for dementia and suggests that new instruments evaluating even broader aspects of cognition, including executive function, will be important in helping to identify dementia at an earlier stage of development- The various behavioral syndromes associated with dementia, with emphasis on the need for great diagnostic clarity to help focus appropriate therapy in this area of increased burden for patients and family caregivers- Biomarkers in dementia that may already be appropriate for inclusion in our diagnostic criteria; the current diagnostic utility of specific imaging modalities, which, combined with expanding ligand technology or markers of genetic predisposition, might further enhance diagnostic accuracy- A review of the tremendous explosion of information in this field, asserting that, with the exception of the rare Mendelian disorders, genetic profiles are not yet ready to make substantial contributions to nosology

Despite all of these exciting findings, the editors state that we are still dealing with primarily clinical syndromes and therefore are still using clinical diagnostic criteria established at consensus conferences. In the spirit of scientific humility, they assert that these experts' views must be considered within the vast and expanding literature related to the dementias. Given the associated but still generally nonspecific biological mechanisms underlying these syndromes, new scientific developments might occur at any time and immediately affect the interpretations and considerations presented here.

This remarkably concise and insightful collection reviews today's--and suggests directions for tomorrow's--important diagnostic and research issues in dementia, and as such is a "must read" for clinicians and researchers alike.

Trey Sunderland, M.D., is with the National Institute of Mental Health in Bethesda, Maryland.

Dilip V. Jeste, M.D., is Estelle and Edgar Levi Chair in Aging; Director, Sam and Rose Stein Institute for Research on Aging; and Distinguished Professor of Psychiatry and Neurosciences at the University of California, San Diego in San Diego, California.

Olesgegun Baiyewu, M.D., is Professor of Psychiatry in the Department of Psychiatry in the College of Medicine at the University of Ibadan in Ibadan, Nigeria.

Paul J. Sirovatka, M.S., is Associate Director for Research Policy Analysis at the Division of Research/American Psychiatric Institute for Research and Education in Arlington, Virginia.

Darrel A. Regier, M.D., M.P.H., is Executive Director of the American Psychiatric Institute for Research and Education and Director of the Division of Research at the American Psychiatric Association in Washington, D.C.