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Contrast Agents I

Contrast Agents I


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About the Book

Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1-2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].


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Product Details
  • ISBN-13: 9783642075964
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Binding: Paperback
  • Edition: Softcover reprint of hardcover 1st ed. 2002
  • Language: English
  • Returnable: Y
  • Spine Width: 0 mm
  • Weight: 750 gr
  • ISBN-10: 3642075967
  • Publisher Date: 15 Dec 2010
  • Depth: 13
  • Height: 235 mm
  • No of Pages: 249
  • Series Title: Topics in Current Chemistry
  • Sub Title: Magnetic Resonance Imaging
  • Width: 155 mm


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