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Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine


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About the Book

The Future of Clinical Research and Health Care: From Empirical to Precision MedicineClinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development.

Robust Biomarkers for Drug Development and Disease TreatmentThe first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers.

Improve Patient Care and Reduce Costs and Side EffectsDespite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.


About the Author: Claudio Carini, Sandeep Menon, Mark Chang


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Product Details
  • ISBN-13: 9781466593862
  • Publisher: CRC Press
  • Publisher Imprint: Crc Press
  • Depth: 25
  • Language: English
  • Returnable: Y
  • Spine Width: 23 mm
  • Width: 157 mm
  • ISBN-10: 1466593865
  • Publisher Date: 27 Mar 2014
  • Binding: Hardback
  • Height: 236 mm
  • No of Pages: 376
  • Series Title: Chapman & Hall/CRC Biostatistics
  • Weight: 707 gr


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Clinical and Statistical Considerations in Personalized Medicine
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Clinical and Statistical Considerations in Personalized Medicine
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