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Attività Antibatterica Di 1,3,4- Ossadiazoli Sostituiti Con Tioli

Attività Antibatterica Di 1,3,4- Ossadiazoli Sostituiti Con Tioli


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About the Book

L'obiettivo principale della ricerca è quello di progettare un inibitore attivo dell'ossadiazolo sostituito da tiolo contro il recettore GlmS di batteri gram-negativi e gram-positivi con approcci antibatterici in silico e in vitro. È stato progettato uno scaffold di 1,3,4-ossadiazolo e la fattibilità sintetica per ottenere lo scaffold. È stato utilizzato il software PyRx. Il ligando si pone con la minore energia libera. Sono stati condotti studi ADMET. Le fasi di sintesi comprendevano 4 diverse reazioni. Come reagenti di partenza sono stati utilizzati acidi carbossilici sostituiti. Tutte le reazioni sono state monitorate mediante TLC. I composti sintetizzati sono stati caratterizzati mediante spettri FT-IR e MASS. L'attività antibatterica in vitro dei composti è stata esaminata e valutata mediante studi sulla concentrazione minima inibitoria. Dai risultati dello studio della MIC, tra tutti i composti, NOV-4 ha mostrato una notevole attività antibatterica contro il ceppo resistente di MRSA (43300) con una MIC di 4,77 µg/L che supera di gran lunga la MIC dello standard, che è risultata moderata e pari a 209,24 µg/L. Da questi risultati si può concludere che lo scaffold progettato mostra una significativa azione inibitoria nei confronti della proteina recettoriale GlmS.


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Product Details
  • ISBN-13: 9786206973713
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 163 gr
  • ISBN-10: 6206973719
  • Publisher Date: 23 Dec 2023
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm


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