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Animal Models of Movement Disorders

Animal Models of Movement Disorders


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About the Book

Part I: Generic Methods of Assessment

1. Why Can't a Rodent Be More like a Man?: A Clinical Perspective

Anne E. Rosser

2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders

Maria Sundvik and Pertti Panula

3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson's Disease through Application of C. elegans Models

Kim A. Caldwell and Guy A. Caldwell

4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson's Disease

Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman

5. Neurological Evaluation of Movement Disorders in Mice

Simon Brooks

6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System

Jenni M. Karl and Ian Q. Whishaw

7. High Throughput Mouse Phenotyping

Sabine M. Hölter and Lisa Glasl

8. MRI of Neurological Damage in Rats and Mice

Mathias Hoehn

9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research

Nadja Van Camp, Yann Bramoullé, and Philippe Hantraye

10. Optical Approaches to Studying the Basal Ganglia

Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress,

David L. Wokosin, and D. James Surmeier

11. Electrophysiological Analysis of Movement Disorders in Mice

Shilpa P. Rao, Véronique M. André, Carlos Cepeda, and Michael S. Levine

Part II: Dopamine Systems

12. Genetic Models of Parkinson`s Disease

Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst

13. 6-OHDA Lesion Models of Parkinson's Disease in the Rat

Eduardo M. Torres and Stephen B. Dunnett

14. 6-OHDA Toxin Model in Mouse

Gaynor A. Smith and Andreas Heuer

15. Rotation in the 6-OHDA Lesioned Rat

Stephen B. Dunnett and Eduardo M. Torres

16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson's Disease Patients Cannot Move Normally

Gordon W. Arbuthnott

17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson's Disease and Stroke

Sheila M. Fleming and Timothy Schallert

18. Rodent Models of L-DOPA-Induced Dyskinesia

Hanna S. Lindgren and Emma L. Lane

19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson's Disease?

Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec

20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)

Michael J. Jackson and Peter Jenner

21. Behavioral Assessment in the African Green Monkey after MPTP Administration

D. Eugene Redmond, Jr.


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Product Details
  • ISBN-13: 9781617792977
  • Publisher: Humana Press
  • Publisher Imprint: Humana Press
  • Depth: 32
  • Height: 257 mm
  • No of Pages: 447
  • Series Title: Neuromethods
  • Sub Title: Volume I
  • Weight: 1065 gr
  • ISBN-10: 1617792977
  • Publisher Date: 15 Sep 2011
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 30 mm
  • Volume: 1
  • Width: 183 mm


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