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Adme and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Adme and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins


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About the Book

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.

- Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
- Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective
- Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
- Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan
- Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain


About the Author: Honghui Zhou is a Senior Director and Janssen Fellow, at Janssen Research & Development, LLC and US head of Pharmacological and Translational Modeling. Board-certified by the American Board of Clinical Pharmacology and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and American College of Clinical Pharmacology (ACCP), he has authored 200 peer-reviewed scientific papers, book chapters, and conference abstracts and co-edited the book Drug-Drug Interactions for Therapeutic Biologics (Wiley, 2013).

Frank-Peter Theil heads nonclinical development at UCB Biopharma. Dr. Theil has authored and co-authored 40 research publications, three book chapters and he has given numerous invited presentations at national and international scientific meetings. He is a member of the American Association of Pharmaceutical Scientists (AAPS) and American Society of Clinical Pharmacology and Therapeutics (ASCPT).


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Product Details
  • ISBN-13: 9781118898642
  • Publisher: Wiley
  • Publisher Imprint: Wiley
  • Depth: 32
  • Height: 284 mm
  • No of Pages: 472
  • Series Title: Hardcover
  • Sub Title: Applications in Drug Discovery and Development
  • Width: 221 mm
  • ISBN-10: 1118898648
  • Publisher Date: 23 Nov 2015
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 25 mm
  • Weight: 1636 gr


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