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Acidi terpenici modificati dalla Boswellia serrata

Acidi terpenici modificati dalla Boswellia serrata


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About the Book

Isolamento e identificazione di triterpinoidi pentaciclici (acidi boswellici) e tetra ciclici (acidi tirucallici) presenti in natura dalla Boswellia serrata. Sintetizzato nuove molecole ibride utilizzando gli acidi boswellici con i FANS e studiato la loro attività antinfiammatoria e antiartritica su modelli in vivo. Miglioramento di una molecola biologicamente potente a partire da una miscela di acidi boswellici presenti in natura, convertendoli in un'unica molecola mediante ossidazione allilica, utilizzando vari agenti ossidanti e ottimizzando il migliore. Le nanoparticelle di acido boswellico sono state preparate e analizzate con la tecnica SEM. Gli acidi boswellici presenti in natura, che sono agenti antinfiammatori, sono di natura lipofila e quindi diventano un fattore limitante in termini di biodisponibilità. Per la prima volta sono stati preparati glicosidi idrosolubili di acidi 11-cheto-β-boswellici. La sintesi di nuovi composti modificati con l'anello A attraverso il riarrangiamento di Beckmann del secondo ordine a partire dall'acido 3-oxo-tircallico è stata valutata per la loro attività antitumorale contro linee cellulari di cancro umano e si è scoperto che i composti modificati con l'anello A hanno mostrato una migliore attività antitumorale specialmente sulla linea cellulare del cancro alla prostata.


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Product Details
  • ISBN-13: 9786207890637
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Sub Title: Attività biologica
  • Width: 152 mm
  • ISBN-10: 6207890639
  • Publisher Date: 31 Jul 2024
  • Height: 229 mm
  • No of Pages: 92
  • Spine Width: 6 mm
  • Weight: 145 gr


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Acidi terpenici modificati dalla Boswellia serrata
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Acidi terpenici modificati dalla Boswellia serrata
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