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Organogel de lécithine Pluronique topique pour le traitement de la douleur

Organogel de lécithine Pluronique topique pour le traitement de la douleur


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About the Book

Des organogels à base de lécithine pluronique ont été formulés comme support topique pour l'administration contrôlée d'acide méfénamique, un médicament analgésique et anti-inflammatoire pratiquement insoluble dans l'eau. Les organogels ont été préparés par un procédé employant respectivement la lécithine et le pluronic comme phase huileuse et phase aqueuse. Le myristate d'isopropyle (IPM) a été utilisé comme solvant organique pour la lécithine, tandis que la gélification a été obtenue par addition lente de phase aqueuse (Pluronic). Dix formulations ont été préparées en utilisant différentes concentrations de lécithine et de pluronic. L'augmentation de la quantité de lécithine a donné lieu à des organogels ayant une viscosité plus élevée et une aptitude à l'étalement plus faible et le même schéma a été suivi lorsque du pluronic à des concentrations variables a été utilisé. Les organogels ayant une viscosité plus élevée se sont révélés plus stables et contrôlaient le taux de libération. Toutes les formulations se sont avérées avoir une valeur de pH comprise entre 5,56 et 5,80, c'est-à-dire dans la plage de pH cutané. Aucune des formulations ne s'est donc révélée irritante pour la peau. La libération in vitro d'acide méfénamique à partir d'organogels a montré que les organogels contenant 2 % de lécithine (F2) donnaient la libération la plus élevée en 8 heures.​


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Product Details
  • ISBN-13: 9786206873228
  • Publisher: KS Omniscriptum Publishing
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 322 gr
  • ISBN-10: 6206873226
  • Publisher Date: 24 Nov 2023
  • Height: 229 mm
  • No of Pages: 180
  • Spine Width: 10 mm
  • Width: 152 mm


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