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Free Radicals and Alzheimer's Disease

Free Radicals and Alzheimer's Disease


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About the Book

Accumulating evidence suggests that oxidative and nitrosative stress plays a major role in the initiation and progression of Alzheimer's disease. This monograph aims to examine in depth and to clarify the role of oxygen- and nitrogen-centred radicals in the pathogenesis of the disease. To this end, cultures of neuronal and glial cells were challenged with amyloid 1-40 and 25-35 peptides and photon emission was continuously measured with the luminol- or lucigenin-amplified chemiluminescence technique in order to demonstrate free radical species. Furthermore, brain slices of hypoxic rats or rats treated with nitric oxide donors were analysed by transmission electron microscopy. The book also pays due attention to the use of free radical scavengers as prophylactic agents and to the potential therapeutic role of iron and copper chelators. The author's own detailed research is complemented by an exhaustive analysis of the relevant literature, with the citation of more than 9000 publications. Free Radicals and Alzheimer's Disease will be a fascinating and invaluable source of information for researchers and clinicians.
About the Author:

Erich K.P. Schiller was born in Hamburg in 1922. In 1940 he became a student of Max Clara, Wolfgang Bargmann and Richard Arwed Pfeifer, and later gained his Medical License at the University of Leipzig and his MD at the University of Essen. For a long period he was involved in research into silicosis at Rheinpreussen Mining Company before joining the Institute of Hygiene and Occupational Medicine at the University of Essen. He then became Head of Experimental Pathology at Cassella Co, Frankfurt and subsequently worked at the Department of Pharmacology and Toxicology, University of Heidelberg, Mannheim and the German Cancer Research Centre, Heidelberg. Dr. Schiller is a member of a number of prestigious societies, including the Anatomische Gesellschaft, the Deutsche Gesellschaft fur Pathologie (German Society of Pathology) and the Pathological Society of Great Britain and Ireland. He has published extensively in the German, English and French languages and is the author of "Free Radicals and Inhalation Pathology," published in 2004. Dr. Schiller was selected for inclusion in the volume "Outstanding People of the 21st Century" published by the International Biographical Centre.


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Product Details
  • ISBN-13: 9783642318054
  • Publisher: Springer Verlag
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Weight: 750 gr
  • ISBN-10: 3642318053
  • Publisher Date: 31 Mar 2014
  • Height: 254 mm
  • No of Pages: 1029
  • Series Title: English
  • Width: 178 mm


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